NR

( Nicotinamide Riboside )

The gold standard in NAD⁺ precursors with the most extensive clinical validation. Our premium NR delivers proven efficacy for energy, longevity, and cognitive health applications backed by over 150 published studies.

Nicotinamide Riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for various cellular processes, including energy metabolism, DNA repair, and signaling pathways. NAD+ levels decline with age, and this depletion has been linked to various age-related diseases. NR has gained significant attention as a potential therapeutic agent due to its ability to boost NAD+ levels, thereby mitigating age-related pathologies. ECA explores the role of NR as an NAD+ precursor, its metabolism, health benefits, and therapeutic potential.

Chemical Profile

Molecular Formula:

C₁₁H₁₅N₄O₅

Molecular Weight:

255.25 g/mol

CAS Number:

1341-23-7

Purity:

≥98.0%

Solubility:

Highly water soluble

Appearance:

White crystalline powder

Stability:

2 years (proper storage)

Clinical Status:

Extensively studied

Well-Characterized Mechanism

NR utilizes the salvage pathway for NAD⁺ biosynthesis through well-understood enzymatic processes

Cellular Entry

NR crosses cell membranes via equilibrative nucleoside transporters for efficient uptake

NAD⁺ Conversion

Sequential phosphorylation by NR kinases converts NR to NMN, then to NAD⁺ via NMNAT

Pathway Activation

Increased NAD⁺ activates sirtuins, improving cellular health and metabolic function

Cellular Benefits

Enhanced energy, repair, and longevity pathways

Clinically Proven Benefits

Validated health benefits across multiple physiological systems

Clinically Validated

Extensive human studies proving safety and efficacy

Healthy Aging

Supports longevity pathways and cellular repair

Mitochondrial Function

Enhances cellular energy production and efficiency

Neuroprotection

Protects neural function and cognitive health

Clinical Research Statistics

150+

Published Studies

2000+

Study Participants

Zero

Serious Adverse Events

15+

Years of Research

50+

Clinical Studies

Quality Certifications

Comprehensive quality assurance and regulatory compliance for global markets

GRAS Certified

Non-GMO Verified

Vegan Compatible

Halal Certified

ISO 22000

GMP Compliant

Application Forms

Versatile ingredient suitable for various delivery systems and formulation types.

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