NR
( Nicotinamide Riboside )
The gold standard in NAD⁺ precursors with the most extensive clinical validation. Our premium NR delivers proven efficacy for energy, longevity, and cognitive health applications backed by over 150 published studies.
Nicotinamide Riboside (NR) is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for various cellular processes, including energy metabolism, DNA repair, and signaling pathways. NAD+ levels decline with age, and this depletion has been linked to various age-related diseases. NR has gained significant attention as a potential therapeutic agent due to its ability to boost NAD+ levels, thereby mitigating age-related pathologies. ECA explores the role of NR as an NAD+ precursor, its metabolism, health benefits, and therapeutic potential.
Chemical Profile
Molecular Formula:
C₁₁H₁₅N₄O₅
Molecular Weight:
255.25 g/mol
CAS Number:
1341-23-7
Purity:
≥98.0%
Solubility:
Highly water soluble
Appearance:
White crystalline powder
Stability:
2 years (proper storage)
Clinical Status:
Extensively studied
Well-Characterized Mechanism
NR utilizes the salvage pathway for NAD⁺ biosynthesis through well-understood enzymatic processes
Cellular Entry
NR crosses cell membranes via equilibrative nucleoside transporters for efficient uptake
NAD⁺ Conversion
Sequential phosphorylation by NR kinases converts NR to NMN, then to NAD⁺ via NMNAT
Pathway Activation
Increased NAD⁺ activates sirtuins, improving cellular health and metabolic function
Cellular Benefits
Enhanced energy, repair, and longevity pathways
Clinically Proven Benefits
Validated health benefits across multiple physiological systems
Clinically Validated
Extensive human studies proving safety and efficacy
Healthy Aging
Supports longevity pathways and cellular repair
Mitochondrial Function
Enhances cellular energy production and efficiency
Neuroprotection
Protects neural function and cognitive health
Clinical Research Statistics
150+
Published Studies
2000+
Study Participants
Zero
Serious Adverse Events
15+
Years of Research
50+
Clinical Studies
Quality Certifications
Comprehensive quality assurance and regulatory compliance for global markets
GRAS Certified
Non-GMO Verified
Vegan Compatible
Halal Certified
ISO 22000
GMP Compliant
Application Forms
Versatile ingredient suitable for various delivery systems and formulation types.
- Capsules & Tablets
- Powder Formulations
- Liquid Supplements
- Functional Beverages
- Sublingual Forms
- Time-Release Systems
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