NRHM (Nicotinamide Riboside Hydrogen Malate)
NRHM is an innovative salt form of Nicotinamide Riboside (NR), a well-studied NAD⁺ precursor. NAD⁺ is a vital coenzyme that supports energy metabolism, DNA repair, and gene regulation. As NAD⁺ levels decline with age, NRHM offers a targeted approach to restore cellular NAD⁺, with potential applications in managing metabolic and age-related conditions.
Senolyte™ NRHM combines the NAD⁺ boosting power of NR with hydrogen malate to improve stability, solubility, and bioavailability. This advanced form supports synergistic metabolic benefits and is engineered for superior formulation performance and consumer experience. Ideal for products focused on longevity, cellular energy, and healthy aging.
Chemical Profile
Active Component:
NR + Hydrogen Malate
Salt Form:
1:1 Stoichiometry
Molecular Formula:
C₁₁H₁₅N₂O₅•C₄H₆O₅
Molecular Weight:
389.35 g/mol
Purity:
≥98.5%
Appearance:
White to off-white crystalline powder
Stability:
Superior
Solubility:
Enhanced water solubility
Advanced Mechanism of Action
NRHM leverages the proven NR pathway while providing enhanced solubility and stability characteristics
Enhanced Stability
Hydrogen malate salt form provides superior stability under various storage and formulation conditions
Improved Solubility
Enhanced water solubility characteristics result in superior bioavailability and faster dissolution
Direct Conversion
Streamlined pathway to NAD⁺ synthesis with reduced metabolic burden on cellular systems
Salt Form Innovation
NRHM represents advanced pharmaceutical chemistry, combining NR with hydrogen malate
to create a superior salt form with enhanced properties and synergistic effects.
Molecular Engineering
Precisely engineered salt form optimizes both stability and bioavailability
Enhanced Absorption
Improved dissolution and cellular uptake compared to standard NR
Synergistic Benefits
Hydrogen malate provides additional metabolic and energy support
Dual-Action Mechanism
NMNH represents a breakthrough in NAD⁺ precursor technology, combining the proven efficacy of NMN
with enhanced stability and additional antioxidant benefits.
NR Component
Provides the proven NAD⁺ boosting benefits through the salvage pathway, enhancing cellular energy and repair mechanisms.
Hydrogen Malate Component
Supports cellular respiration and energy metabolism through the citric acid cycle, providing additional metabolic benefits.
Synergistic Effect
Combined action results in enhanced cellular energy production, improved performance, and comprehensive metabolic support.
Key Benefits
Senolyte™ NRHM is produced using ECA’s proprietary crystallization techniques, which combine nicotinamide riboside
with hydrogen malate to form a stable salt with enhanced nutraceutical properties and formulation benefits.
Superior Stability
Enhanced shelf-life and resistance to degradation
Synergistic Effects
Combined benefits of NR and hydrogen malate
Enhanced Bioavailability
Improved absorption and cellular delivery
Metabolic Support
Enhanced cellular energy and metabolic function
Research Pipeline
Preclinical Studies
Comprehensive in vitro and animal studies demonstrating enhanced bioavailability and efficacy
Safety Assessment
Extensive toxicology studies confirming safety profile consistent with parent compound NR
Clinical Development
Phase I human studies planned to validate enhanced properties and establish dosing guidelines
Comparative Advantages
NRHM demonstrates superior properties compared to standard NR formulations
Stability Enhancement
*Storage at 25°C/60% RH in HDPE bottles
Bioavailability Improvement
*Pharmacokinetic study, single 300mg dose
Development Status
NRHM is advancing through comprehensive development programs to validate its enhanced properties
8+
Preclinical Studies
40%
Bioavailability Improvement
2X
Stability Enhancement
Quality Certifications
Comprehensive quality assurance and regulatory compliance for global markets
GRAS Certified
Non-GMO Verified
Vegan Compatible
Halal Certified
ISO 22000
GMP Compliant
Application Forms
Versatile ingredient suitable for various delivery systems and formulation types.
- Capsules & Tablets
- Powder Formulations
- Sports Performance
- Energy Formulations
- Anti-Aging Blends
- Metabolic Health
Advance Your Formulations with NRHM
Stay ahead of the curve with this enhanced NAD⁺ precursor designed for next-generation longevity products.
